Companies must determine the replacement time of machine parts correctly since it a , ects their production costs and e, ciencies. In this respect, the objective is to determine the most appropriate replacement time to minimize cost per unit. This study proposes developing a hybrid Arti, cial Neural Network (ANN)-Genetic Algorithm (GA) model to predict replacement time without using a cost model. At , rst, a replacement cost model is developed to calculate replacement times to use in training the neural network. Nevertheless, the cost model needs complex mathematical calculations. GA is used instead of the cost model to determine replacement time and thus, to achieve fast learning for the neural network. The hybrid ANN-GA model was applied to predict replacement time of bladder in tire manufacturing. Furthermore, ANN and GA models, which were developed to increase the prediction accuracy of the hybrid model, were used. The hybrid ANN-GA model presented a better solution according to the performance statistics than the other ANN and GA models. The values indicate that the hybrid model is in good agreement with the cost model. Thus, it is recommended that the hybrid model be used instead of the cost model.